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+--- Thread: Camelid single domain antibody (sdAb) service by GenScript (/thread-2716.html)
Camelid single domain antibody (sdAb) service by GenScript - GenscriptUSA - 12-11-2013
The use of camelid heavy chain antibodies (HCAbs) in antibody engineering is becoming popular. It differs from standard IgG antibodies in that it is significantly smaller, with 6 total domains that consist of two heavy chains, each with a variable region (VHH) and two constant regions (CH2 and CH3). The VHH domain is actually a fully functional antibody fragment, hence its name single domain antibody (sdAb).
Because of its small 13kDa size, sdAbs have the advantage of better tissue penetration, and binding to hidden epitopes. An example of this is in HIV-1 vaccine development. Researchers have discovered that these small single domain antibodies can bind to the gp140 envelope glycoprotein to prevent interaction with cell CD4 receptors and neutralize over 95% of circulating HIV-1 isolates*.
SdAbs are revolutionizing the next-generation of antibody therapeutics and GenScript is pleased to offer sdAb engineering services along with our other cutting-edge antibody engineering services and expertise.