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Basic learning required for drug designing
#1
This is post no. 1 under the main topic.
hi friends,
   I'm pursuing doctrate which has drug designing part. I know somewhat but not good enough to carry out this part. pls help me by suggesting some books , websites, tutorials for knowing the basics and practical bioinformatics to know about protein structure retrieval,  protein information retrieval, docking etc..

pls help me friends. thank you for all
Bv ram- I'm student for all those who teaches me
 
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#2
This is post no. 2 under the main topic.
(07-22-2015, 05:57 PM)bvs science freak Wrote: hi friends,
   I'm pursuing doctrate which has drug designing part. I know somewhat but not good enough to carry out this part. pls help me by suggesting some books , websites, tutorials for knowing the basics and practical bioinformatics to know about protein structure retrieval,  protein information retrieval, docking etc..

pls help me friends. thank you for all

Hi,

Autodock has quite an exhaustive manual with crisp description of active-site - ligand docking/interaction. There are ample video tutorials for the same on youtube as well (believe me, they are among-st the best and most easily comprehendable). You may try Autodock vina too (minimal need for user interference). But I would suggest going for Autodock, than Vina.

Best book to follow for Molecular Modeling and learning basic and advanced concepts for drug designing would be Andrew Leach's [b]Molecular Modelling: Principles and Applications.[/b]

I strongly suggest against the use of multiple books and tools (you will end up confusing yourself).

For protein structure and information retrieval, digging deep into PDB is the best shot.

Following info from PDB will be of use (taken as it is from the website):
Best wishes
Sunil Nagpal
MS(Research) Scholar, IIT Delhi (Alumnus)
Advisor for the Biotech Students portal (BiotechStudents.com)
Computational Researcher in BioSciences at a leading MNC


Suggested Reads:
Top Biotech Companies | Top places to work
Indian Biotech Companies and Job Openings
Aiming a PhD in Top Grad School? | These are the Important Points to Consider
Careers in Biotechnology | A list of various Options
Biotechnology Competitive Exams in India
 
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#3
This is post no. 3 under the main topic.
Thank u very much MR. Sunil Nagpal. I'll follow all those n enrich myself.If I've a doubt can i clarify with you?
Bv ram- I'm student for all those who teaches me
 
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#4
This is post no. 4 under the main topic.
(07-24-2015, 03:00 PM)bvs science freak Wrote: Thank u very much MR. Sunil Nagpal. I'll follow all those n enrich myself.If I've a doubt can i clarify with you?

Please feel free, I'll be glad to assist (to whatever extent I can).

Best wishes!
Sunil Nagpal
MS(Research) Scholar, IIT Delhi (Alumnus)
Advisor for the Biotech Students portal (BiotechStudents.com)
Computational Researcher in BioSciences at a leading MNC


Suggested Reads:
Top Biotech Companies | Top places to work
Indian Biotech Companies and Job Openings
Aiming a PhD in Top Grad School? | These are the Important Points to Consider
Careers in Biotechnology | A list of various Options
Biotechnology Competitive Exams in India
 
Reply
#5
This is post no. 5 under the main topic.
I tried downloading autodock but i couldn't so far.how can i download and install?...or can u give me a link to download direct software. so that it will be helpful to follow the advice you gave for learning drug design
Bv ram- I'm student for all those who teaches me
 
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#6
This is post no. 6 under the main topic.
am using windows 7 os
Bv ram- I'm student for all those who teaches me
 
Reply
#7
This is post no. 7 under the main topic.
Hi,

You should be able to download Autodock from:
http://autodock.scripps.edu/downloads

The following tutorial would be great for you to start with the minimal requirements for the entire set-up:





Following one for Vina:



Hope it helps..

Let me know if there is any other query.

Best wishes
Sunil Nagpal
MS(Research) Scholar, IIT Delhi (Alumnus)
Advisor for the Biotech Students portal (BiotechStudents.com)
Computational Researcher in BioSciences at a leading MNC


Suggested Reads:
Top Biotech Companies | Top places to work
Indian Biotech Companies and Job Openings
Aiming a PhD in Top Grad School? | These are the Important Points to Consider
Careers in Biotechnology | A list of various Options
Biotechnology Competitive Exams in India
 
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#8
This is post no. 8 under the main topic.
Thank you once again
Bv ram- I'm student for all those who teaches me
 
Reply
#9
This is post no. 9 under the main topic.
(07-23-2015, 04:26 PM)SunilNagpal Wrote:
(07-22-2015, 05:57 PM)bvs science freak Wrote: hi friends,
   I'm pursuing doctrate which has drug designing part. I know somewhat but not good enough to carry out this part. pls help me by suggesting some books , websites, tutorials for knowing the basics and practical bioinformatics to know about protein structure retrieval,  protein information retrieval, docking etc..

pls help me friends. thank you for all

Hi,

Autodock has quite an exhaustive manual with crisp description of active-site - ligand docking/interaction. There are ample video tutorials for the same on youtube as well (believe me, they are among-st the best and most easily comprehendable). You may try Autodock vina too (minimal need for user interference). But I would suggest going for Autodock, than Vina.

Why is Autodock better than Autodock Vina?
 
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