Tumor-killing Guinea Pig enzyme finally characterized, 60 years later - Printable Version +- Biotechnology Forums (https://www.biotechnologyforums.com) +-- Forum: Information (https://www.biotechnologyforums.com/forum-16.html) +--- Forum: News (https://www.biotechnologyforums.com/forum-15.html) +--- Thread: Tumor-killing Guinea Pig enzyme finally characterized, 60 years later (/thread-6675.html) |
Tumor-killing Guinea Pig enzyme finally characterized, 60 years later - lorrainegenscript - 11-12-2014 After a 1953 paper revealed that guinea pig serum could kill tumor cells through L-asparaginase activity, several bacterial L-aspariginases were developed as FDA-approved drugs to treat acute lymphoblastic leukemia (ALL) and other cancers. However, side effects persist due to off-target glutaminase activity and immunogenicity, so researchers recently went back to the original source: the guinea pig. 60 years after that first report, they've now characterized a guinea pig enzyme they say should replace currently-used cancer drugs; |