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Why Proline doesn't favour formation of alpha helix? - Printable Version

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Why Proline doesn't favour formation of alpha helix? - Fazlil - 09-30-2017

Why Proline doesn't favour formation of alpha helix?


RE: Why Proline doesn't favour formation of alpha helix? - Lavkeshsharma - 09-30-2017

(09-30-2017, 02:20 PM)Fazlil Wrote: Why Proline doesn't favour formation of alpha helix?

The 5 - membered ring of proline prevents rotation about alpha C - N bond and proline introduces a destabilizing kink in the alpha helix. In addition proline residue linked by an amide bond doesn't have a hydrogen atom to form hydrogen bonds with other residues. Therefore, Proline is also Known as Helix breaker.