[ExpertScie]

Here are the structural characteristics, replication method and WHO categorization of Ebola virus.
These are thread like structure when observed under electron microscope. It has around 288 amino acids. The virions are tubular in form but overall shape varies and appears as shepherds crook or eyebolt. Virions are generally 80nm in diameter with bilayer of lipid anchoring the glycoprotein.
This also has 7 to 10 nm of long spikes projecting from its surfaces. They are 800 nm in length but may vary up to maximum 1000 nm long. The nucleocapsid is in the centre and is form by the helical wound RNA complex with protein VP30,NP,VP35 and L.
Apart from unique structural characteristics, replication of virus takes place with use of machinery and metabolism (enzymes) of host cells. They produce multiple copies of themselves and assemble within the cell.
During replication, virus attaches to host receptors through the glycoprotein surface. Translation of the mRNA into viral protein occurs by using host cells machinery. They destroy the cell at the end of their own replication. Thus affect host. The break out of Ebola Virus Disease also known as EVD is due to Ebola virus infection and spread.
EBOV is one of four ebolaviruses that is responsible for Ebola virus disease (EVD) in humans. In the past, EBOV has caused the many EVD outbreaks.
Due to such importance of this virus in out breaks, World Health Organization has categorized it under
Risk Group 4 Pathogen. This means that they require Biosafety Level 4 or equivalent containment. Stringent environmental conditions are required while handling them in lab and in various research labs.