Antibacterial wound dressings
The original article in this thread describes the use of anti-microbial coatings for bandages and other materials used in hospital settings aimed at killing bacteria. Recent research in this field is using different methods and techniques to create dressings that provide an aseptic environment to allow wound healing and is mindful of the issues around multi-drug resistance to antibiotics.
One study from Charles University in Prague in the Czech Republic have tested a new antibacterial material made from Tecophilic() nanofibre textile (NT). This was prepared by electrospinning techniques and impregnated with a tetraphenylporphyrin (TPP) photosensitizer which is activated by visible light to produce short-lived, highly reactive singlet oxygen O(2) ((1) Δ(g) which are antibacterial . The material was tested both in vitro on 3 bacterial strains and in vivo on patients with chronic leg ulcers. Complete inhibition of growth of the three tested bacterial strains was observed in vitro. In vivo, wound size and pain associated with wounds was reduced in more than half the patients tested. The authors maintain that this material presents a potential alternative to topical antibiotics and antiseptics.
Another novel study from the Rensselaer Institute in the USA mimicked nature by immobilising a cell lytic enzyme called lysostaphin (Lst) on to bandages. This idea mimics the strategy used by bacteriophages and bacteria in nature, in which cell lytic enzymes are used to kill host or competing bacteria respectively. Lst-functionalized cellulose fibers were created by electrospinning techniques and used to make bandages which were tested in an in vitro skin model. The bandages displayed specific bactericidal activity against the bacteria S. aureus but with low toxicity toward keratinocytes. These may therefore be effective materials for use as antimicrobials in wound healing.
Sources
ARENBERGEROVA, M. et al., 2012. Light-activated nanofibre textiles exert antibacterial effects in the setting of chronic wound healing. Denmark: Munksgaard.
MIAO, J. et al., 2011. Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications. Biomaterials, 32(36), pp. 9557-9567
The original article in this thread describes the use of anti-microbial coatings for bandages and other materials used in hospital settings aimed at killing bacteria. Recent research in this field is using different methods and techniques to create dressings that provide an aseptic environment to allow wound healing and is mindful of the issues around multi-drug resistance to antibiotics.
One study from Charles University in Prague in the Czech Republic have tested a new antibacterial material made from Tecophilic() nanofibre textile (NT). This was prepared by electrospinning techniques and impregnated with a tetraphenylporphyrin (TPP) photosensitizer which is activated by visible light to produce short-lived, highly reactive singlet oxygen O(2) ((1) Δ(g) which are antibacterial . The material was tested both in vitro on 3 bacterial strains and in vivo on patients with chronic leg ulcers. Complete inhibition of growth of the three tested bacterial strains was observed in vitro. In vivo, wound size and pain associated with wounds was reduced in more than half the patients tested. The authors maintain that this material presents a potential alternative to topical antibiotics and antiseptics.
Another novel study from the Rensselaer Institute in the USA mimicked nature by immobilising a cell lytic enzyme called lysostaphin (Lst) on to bandages. This idea mimics the strategy used by bacteriophages and bacteria in nature, in which cell lytic enzymes are used to kill host or competing bacteria respectively. Lst-functionalized cellulose fibers were created by electrospinning techniques and used to make bandages which were tested in an in vitro skin model. The bandages displayed specific bactericidal activity against the bacteria S. aureus but with low toxicity toward keratinocytes. These may therefore be effective materials for use as antimicrobials in wound healing.
Sources
ARENBERGEROVA, M. et al., 2012. Light-activated nanofibre textiles exert antibacterial effects in the setting of chronic wound healing. Denmark: Munksgaard.
MIAO, J. et al., 2011. Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications. Biomaterials, 32(36), pp. 9557-9567
![[+]](https://www.biotechnologyforums.com/images/netpen-pro/collapse_collapsed.png)