[Lavkeshsharma]

How does it can help in biology? Its just inquisitiveness

This technique which is called cryo-electron microscopy, allow biomolecules to be visualised in their natural configuration for the first time, triggering a revolution in biochemistry. The latest versions of the technology mean scientists can record biochemical processes as they unfold in film-like sequences.

Earlier imaging techniques, such as X-ray crystallography, required samples to be studied in a rigid state, revealing little about the dynamics of proteins and enzymes – many of which could not be successfully crystallised in any case. Another microscopic technique, the electron microscope, was only suitable for imaging dead matter, because its powerful beam destroyed delicate biological structures.

Cryo-electron microscopy has allowed scientists to explore the architecture of everything from the proteins that cause antibiotic resistance to the surface of the Zika virus. Last year the 3D structure of the enzyme producing the amyloid of Alzheimer’s disease was published using this technology. By capturing snapshots of the same system at different time-points, scientists can even stitch together jittery film sequences of biological processes as they unfold.

This has paved the way for both new basic insights into life’s chemistry and for the development of pharmaceuticals.