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Poll: Nature always gives chance to everyone and is well balanced; with infections as well as immunity to it. Therefore Is it only depends on us what we opt?
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Yes, if we follow good health guidelines, we can improve our immunity
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No, we are bound to get infected with pathogenic bacteria and viruses in spite of strong immune system.
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This will be true only when Humans will develop immunity against Viruses like HIV also.
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Keep your immune system strong and healthy !
#1
Microorganisms are Omni-present and due to this, there is always a chance that they can infect humans and other animals especially when they are immunologically feeble. Therefore it is very important to keep our immune system strong and there are many strategies for the same. Immune system has three lines of defense which includes skin, various barriers for infections and WBC’s which includes macrophages and various plasma cells.
But for us the first line of defense is to follow a healthy lifestyle. To keep our immune system strong and healthy, we need to follow good health guidelines. When we adhere to such guidelines, these not only boost our immune system but also improve capability of each and every system of our body. When your immune system is strong, your whole body and its all systems follow the same path of becoming strong. Few guidelines which can keep your immune system strong and healthy are:

• Exercise regularly for minimum 30 minutes.
• Maintain a healthy weight that is body mass index.
• Don’t smoke.
• Adhere to good practices for improving personal hygiene and follow
steps to avoid infection, such as washing your hands frequently,
try to adapt with various environments with exposures.
• Get adequate sleep for minimum of 7-8 hours.
• Eat a diet high in fruits, vegetables, and whole grains, and low in
saturated fat.
• Track your blood pressure and control it.
• If you drink alcohol, drink only in moderation.
• Get regular medical screening and take necessary precautions as
recommended.
• And the most important is to live happy and stress free life.

Nature always gives chance to everyone and is well balanced; with infections as well as immunity.
Now it only depends on us what we opt!
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#2
Obesity and the innate immune response

The benefits of a healthy lifestyle are extolled in the previous article to help maintain a healthy immune system. In fact, many scientific studies support the article’s contention that the first line of defence is a healthy lifestyle. One public health issue that has become extremely problematic in the developed world is that of obesity. Various recent studies suggest that, for example, obesity has a direct effect on elements of the innate immune system. For example a recent Journal of Immunology paper from the University Of Louisville School Of Medicine in the USA looked at alterations in inflammation resolution in obesity and type 2 diabetes. There is much evidence that the excess of nutrients in obesity result in chronic low-grade inflammation, although the mechanism remains unclear. Obese people also experience defective wound healing and are more susceptible to infections. This study looked specifically at a potential role for prostaglandins in inflammation resolution defects in obesity. The study on a mouse model of obesity/diabetes found that saturated free fatty acids that are elevated in obesity promote neutrophil survival and decrease macrophage phagocytosis, thus altering inflammation resolution. Furthermore, in isolated macrophages it was observed that the free fatty acid palmitic acid induced cyclooxygenase-2 and increased prostanoid production. These palmitic acid-induced macrophage phagocytosis effects could be mimicked by the prostaglandins PGE2 and PGD2 and reversed by cyclooxygenase inhibition or prostanoid receptor antagonism. Macrophages from the mouse model of obesity/diabetes expressed the prostanoid receptors EP2 (PGE2 receptor) and DP1 (PGD2 receptor) and had higher levels of the prostanoid receptor downstream signalling molecule cAMP than wild type mice. Importantly, the EP2/DP1 dual antagonist AH6809 reduced effects of impaired inflammation resolution including peritoneal neutrophil accumulation and thymic apoptotic cell accumulation. Thus, the study identified prostanoid receptors as a potential novel therapeutic target in resolution of inflammation in obesity and diabetes. However, as the original article recommends, prevention is better than cure and a healthy diet combined with adequate exercise is the best method to avoid obesity and its associated immune response problems.

Source

HELLMANN, J. et al., 2013. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. Journal Of Immunology (Baltimore, Md.: 1950), 191(3), pp. 1383-1392
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