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New Discovery for Migrane Treatment - Migraine Genetic Link
#1
Migraine is neurological chronic disorder. Characteristic of this disorder is recurrent headache which can be very severe. Sometimes, these headaches could be followed with some autonomic nervous system symptoms. Other symptoms like nausea, vomiting, photophobia and phonophobia can occur as well.

Migraines are considered as both environmental and genetic disorders. Because two- thirds migraine patients have positive family anamnesis, scientists focused on genetic research in order to discover which genetic links are responsible for migraine incidence. Also, two- thirds of patients are women, and it shows that female hormones like estrogen have significant role in migraine development.

However, many migraine suffering people can be optimistic, because scientists on Brigham Young University revealed their newest discoveries, and results are in every way promising to scientists.

Professor at Brigham Young University (BYU), Emily Bates suffered severe migraine attacks when she was young, and she decided to dedicate all her knowledge to research migraine cause. According to latest findings she has done great job, and now she is one step closer to complete understanding of migraine disorder.

Considerations of migraine genetic basis

Professor Bates and other two lead researchers discovered two gene families with very similar genetic mutations. They tested these genetic mutations on mice, and results were encouraging. They hope that these results will stimulate research for effective medicines for migraine attacks. While single mutation is not that common (scientific project that included 27,000 people), position of mutation and normality of the symptoms suggest this study can influence on many patients with migraine disorder.

Role of the transformed gene

It is discovered that mutation occurs when an enzyme, casein kinase delta (CKlδ), becomes an impared enzyme. Mutated gene has many functions in cell. One of the most important gene roles is removal of waste and neural transmitters. In comparison with other genes, discovered from various studies, this gene can hit on common causes of migraine. Other genes are connected with severe or rare forms of migraine disorder.

Directions for future researches

Scientists can see several malformations in brain cell cultures with mutated genes. First of all, neurons are completely normal. However, problem occurs in astrocytes cells. These cells show unusual behavior. Astrocytes are specialized neural cells, and they present bigger cell family then neurons. In neural tissue, astrocytes have function to remove extra neural transmitters and other waste. Mutated astrocytes have another behavior, and they can make brain blood vessels hyperactive and hyper- responsive to brain activity. This phenomenon can cause migraine pain.

Role of the estrogens in migraine pain

Steroid hormones mediate their activity via their receptors, which are widely distributed in human organism. Estrogen receptors are founded in some brain regions which are considered as potentially involved in migraine disorder pathogenesis. Lower level of estrogen in human body is important migraine trigger. When woman has low level of estrogen after exposure to high levels of the hormone for several days, estrogen- associated migraine can occur.

The mutated gene is also responsible in estrogen induced migraine pain. This gene codes a protein that interacts with estrogen receptors. According to this, women are more vulnerable for this disorder development. This theory can very likely explain why women are two- thirds of all migraine patients.

Particular gene mutations associated with sleeping disorder

Analyzing individual genes with plenty of common genes is not that simple. Often, scientists find it difficult, because they cannot focus on target genes. However, they found out that rare sleeping disorder is related to migraine. After that discovery, they included two families with migraine pain associated with rare sleeping disorder in study. This sleeping disorder is very unusual. Patients with this syndrome fall asleep at 7 p.m. and wake up 4 a.m.

Importance of this discovery is that scientists have never been so confident that one gene is related to migraine disorder. When they are so confident about this discovery, it is just a matter of time when they will find medications for migraine disorder.

Researches on mice

When scientist found out which gene is related to migraine disorder, they began experiments on mice. The goal of this experiment was evidence that mutation of certain gene causes migraine- symptoms in another mammals.

Results were measured in two ways. One researcher tried to compare mice brain activity with human brain results like auras, fuzzy lights and vision loss. On the other side, another team of researchers, led by professor Bates, tried to measure characteristic pain and sensitivity in mice. They used nitroglycerine for mice migraine test, substance which is used for chest pain in human, and induces migraine in human population. Both ways have shown that mutated genes can induce migraine in mice, further solidifying the connection between migraines in humans and mutated gene.

Conclusion

Migraines are not so good researched topic in medicine. Traditionally, these disorders are difficult to treat, not just because of their complexity, but because scientists and doctors know so little about them. Every single drug used in treatment of migraine is created for another health disorder. However, these drugs are used with certain dose of efficiency in treatment of the symptoms, but for patients, much more is needed. Discovery of mutation, when casein kinase delta (CKlδ) becomes impaired, offers promising solutions for new ways of migraine treatment and drug development. Unfortunately, it will take many years from now to bring such drugs to market, but these medications could possibly help more than 12 percent of people on the globe. This experiment and its results are just a first step on a long way of revolutionary discovery, and if scientist want to improve their knowledge about migraine, they will have to look in finer parts of genetic pathway.
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#2
Its very complex thing the odd thing i find in this is its made by creating health disorder, anyways a friend of mine here with me in aged home is facing this migraine so its really a good new for him, its better to see some improvements.
Supported living Australia
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New Discovery for Migrane Treatment - Migraine Genetic Link00