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Vitamin E protective against cognitive impairment
#1
The findings of a new study from the University of Eastern Finland may suggest that including sources of vitamin E in the diet, such as vegetable oils including palm oil, sunflower, corn, soybean and olive oil or using vitamin E supplements, could confer an advantage in avoiding memory disorders in later life. The study, published in Experimental Gerontology, found that elevated serum levels of various vitamin E forms was associated with decreased risk of development of cognitive impairment. Vitamin E is a fat-soluble vitamin in eight forms, four tocopherols and four tocotrienols and is an important anti-oxidant. To date one form, α-tocopherol , which is found in many vitamin E supplements, has been focused on in studies of cognitive impairment and Alzheimer's disease. However the Finnish study suggests that other forms of vitamin E, including γ-tocopherol, β-tocotrienol and total tocotrienols, are associated with the observed protective effect.

The study focused on a sample of 140 Finnish people over the age of 65 who had no memory impairment at the beginning of the 8-year study. The study population was drawn from participants in the more extensive Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study, which examines links between cardiovascular disease and memory impairment. For the purposes of the study, cognitive impairment was defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. Lower risk of cognitive impairment was observed in subjects with higher absolute serum levels of γ-tocopherol, β-tocotrienol, and total tocotrienols. The study highlights the importance of considering all forms of vitamin E when considering vitamin E status and suggests a further benefit of including vitamin E in the diet.

Sources

MANGIALASCHE, F., SOLOMON, A., KÅREHOLT, I., HOOSHMAND, B., CECCHETTI, R., FRATIGLIONI, L., SOININEN, H., LAATIKAINEN, T., MECOCCI, P. and KIVIPELTO, M., 2013. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Experimental Gerontology, 48 (12): 1428 DOI: 10.1016/j.exger.2013.09.006

University of Eastern Finland. "Several forms of vitamin E protect against memory disorders, study says." ScienceDaily, 7 Jan. 2014. [Accessed 8 Jan. 2014].
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#2
Some saw this as an indication the vitamin simply does not work. Lon Schneider, University of Southern California, Los Angeles, said that given the high dropout rate and baseline heterogeneity in each group, any benefit in the vitamin E group may have arisen by chance, especially since it disappeared in combination with memantine and went unsupported by secondary outcomes.
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