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Understanding the Basics of Tuberculosis
#5
Hello Maureen, I am as fit as a fiddle and I hope you are doing fine as well.  Big Grin

You have actually brought up a good and valid point here.

Firstly, I feel that people who suffer from TB and HIV have a certain social stigma. They avoid going for check-ups and almost give up on any hopes of surviving. They hardly want to socialise and turn into recluses. Also, if you see, both HIV and TB cases are really tricky to diagnose. And when an HIV infected patient has TB, the case may turn more complex because of lack of good medical facilities. Hence, why not think about adopting something like DOTS for HIV patients as well?

The only hindrance to a DOTS-like programme for HIV is that TB is actually curable but HIV-AIDS is not.

BUT the later can definitely be controlled.
So, if a similar programme can come up for AIDS, I am sure that it would help the HIV infected patients to keep a check on their health and avoid infections. These programmes can educate them on how to keep small infections at bay, so that even with a compromised immunity system, they can lead a normal life.

I am a big advocate for a strategy that includes some get-togethers and activities, which might motivate the patients to live life to the fullest.

One of the main objectives of DOTS is to provide free of cost medicines to TB patients and if a similar strategy is adopted for AIDS, the patients would benefit hugely from it. But HIV-AIDS drugs can be costly, especially the branded ones and it may not be feasible for them to be provided for free. Generic drugs are much cheaper and can definitely be thought of as safe, low-cost alternatives.

The protocol for diagnosis of HIV needs to be quick, reliable and uniform across the country.

 Also, systematic recording of the patients’ data and keeping them under constant supervision can be effective in bringing down the number of deaths caused by AIDS. This has to be lifelong though, as unlike TB which gets cured in 6 to 9 months, AIDS doesn’t.

And as per HIV-TB infections are concerned, DOTS can be followed to get rid of the mycobacterial infection.

There have been many reports where various AIDS specific strategies are being devised and trials are going on. But none of them are yet to be implemented on a large scale.

I live in India and almost everyday, I see so many advertisements starring big celebrities, informing people about DOTS and I think, if such a programme is launched for AIDS as well, the patients would be happy to get some support, both medically and mentally.

Well, there are some obvious problems with an AIDS strategy but the thought is novel and I hope that a support system for AIDS patients is launched soon; for this world is as much theirs as it is for us!

Have a nice day Maureen!
#6
A NEW DEVELOPMENT  Angel


 
The Indian city of Gurgaon saw the launch of mobile vans which will go around the districts of Haryana in search of active cases of TB.  It is the collaboration of  the Government of Haryana along with Medanta - The Medicity hospital, United States Agency for International Development (USAID), the International Union Against Tuberculosis and Lung Disease, and the Central TB Division of the Ministry of Health & Family Welfare (Government of India).
 
The vans are fitted with X-ray machines and there are facilities for receiving outcomes of the tests instantly. The district doctors would then be approached for further confirmation and thereafter, the patients would be asked to undergo GeneXpert testing which can detect M. tuberculosis DNA. After the confirmations, the patients would be referred to primary health care centres for DOTS.


[Image: hospital-medicity-november-november-hind...59308e.jpg]
 A van to be used in this programme



These vans can screen up to fifty people per day. This is a weekly, three phased programme, spanning across five years.

As discussed earlier in this thread, there is a social stigma attached to this disease and this is definitely a welcome step to curb the fatal cases of TB, which in most cases may go undetected.

 

 References:


http://www.thehindu.com/todays-paper/tp-...901899.ece
http://www.hindustantimes.com/gurgaon/go...Jk6SN.html
http://www.tribuneindia.com/news/haryana...60755.html





A note will follow soon on GeneXpert for TB.
#7
New research shows daily antibiotics may prevent drug-resistant TB and quicken recovery!


A study published recently in the journal BMC Systems Biology claims that the prescriptions advising doses of medicines only once or twice a week may give rise to more cases of drug resistant strains of M. tuberculosis in comparison to the ones which suggest antibiotics on a daily basis. Most probably the considerable gap between the doses gives the bacteria ample time to adapt to the antibiotic induced adverse conditions.

This entire study was based on a computer simulation model fed with information collected from earlier experiments on rabbits and monkeys. They studied the effects of standard drugs like  isoniazid and rifampin with respect to their efficiency at varied doses and future prospects.

The doses comprised of larger doses once or twice a week and small daily doses. Computer simulations showed that that daily treatment was way more effective, though even in this case their was dificulty in wiping off the entire bacterial population due to granulomas or/and passive state of reproduction.  

The team tried to find out the dose frequency which would be most effective in raising antibiotic concentration inside the granuloma and found the daily regime to be more potent. The study shows that nine doses per week (evening and morning doses two days per week and rest of the days having single doses) is the quickest way to get rid of all the bacteria.

The work was done by University of Michigan in collaboration with National Institutes of Health, with computing resources provided by the National Energy Research Computing Center, Open Science Grid, and Extreme Science and Engineering Discovery Environment.


References:

http://timesofindia.indiatimes.com/life-...908816.cms
http://www.ndtv.com/health/daily-antibio...is-1247146
http://www.rdmag.com/news/2015/11/tuberc...nt-strains
http://ns.umich.edu/new/releases/23321-t...nt-strains

[url=http://www.rdmag.com/news/2015/11/tuberculosis-daily-antibiotics-recommended-prevent-resistant-strains][/url]
#8
(11-24-2015, 11:28 PM)APARAJITA AICH Wrote: New research shows daily antibiotics may prevent drug-resistant TB!



Read more here:


http://timesofindia.indiatimes.com/life-...908816.cms

Hi Aparajita,

Really appreciate your posts here. It would be nice if you could post the details of the information than the exit link. It's sort of against the forum rules to post out links (forum is more about giving a platform to discuss and ponder, if people start leaving the forum for out links of info, it will completely loose its meaning).. Hope you understand. Thanks for your co-operation.

Regards,
Editor
  




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