06-19-2015, 07:38 PM
(This post was last modified: 06-19-2015, 07:56 PM by stevewoods.)
Your question about distinguishing between ALS and Alzheimer's disease is appreciated. Very few people tend to ponder over this. It is a fact that ALS and Alzheimer's (and almost every neurodegenerative disease) share quite a lot of common features.
Following are some intriguing similarities between almost every neuro-degenrative disease (be it ALS/Alzheimer's/Parkinson's):
Increased instances of protein misfolding, with marked decrease in recycling. This leads to accumulation of potentially toxic proteins/structures.
Misfolded proteins tend to spread from cell to cell, leading to a sort of spreading of degeneration.
Increased Neuro-inflammation.
But at the level of symptoms, one can easily distinguish ALS from Alzheimer's:
Alzheimer's is more a dysfunction of memory associated skills, which includes loss of memory, difficulty in concentration, mood swings, difficulty in solving regular tasks/problems, confusion with time/places/relationships. On the other hand, ALS is more associated with movement/co-ordination problems like Difficulty walking, tripping or difficulty doing the normal daily activities (in terms of ability to move). Weakness of leg/feet/ankles, trouble in swallowing/speaking, muscle cramps/twitches etc.
Is Alzheimer's Inherited?
The answer is "YES" and "NO"
Whereas early onset Alzheimer's is inheritable, late onset Alzheimer's isn't that inheritable (it's more age associated)
Following are some intriguing similarities between almost every neuro-degenrative disease (be it ALS/Alzheimer's/Parkinson's):
Increased instances of protein misfolding, with marked decrease in recycling. This leads to accumulation of potentially toxic proteins/structures.
Misfolded proteins tend to spread from cell to cell, leading to a sort of spreading of degeneration.
Increased Neuro-inflammation.
But at the level of symptoms, one can easily distinguish ALS from Alzheimer's:
Alzheimer's is more a dysfunction of memory associated skills, which includes loss of memory, difficulty in concentration, mood swings, difficulty in solving regular tasks/problems, confusion with time/places/relationships. On the other hand, ALS is more associated with movement/co-ordination problems like Difficulty walking, tripping or difficulty doing the normal daily activities (in terms of ability to move). Weakness of leg/feet/ankles, trouble in swallowing/speaking, muscle cramps/twitches etc.
Is Alzheimer's Inherited?
The answer is "YES" and "NO"
Whereas early onset Alzheimer's is inheritable, late onset Alzheimer's isn't that inheritable (it's more age associated)