Contact: to feature here

Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
Scientists Successfully Develop HIV-Resistant T-cells !
Thumbs Up 
Yes, another breakthrough in science and Science is made for that!

Scientists successfully develop HIV resistant T-Cell. The technique which creates HIV- resistant cells is discovered now. It means that HIV positive patients can have an alternative to a lifelong medication schedule which is currently followed. HIV is dangerous only because of the virus’ capability to break into and eliminate T Cells

Two genes namely CXR4 and CCR5 helps virus to breach the T cells. These are receptive to the virus. The new technique is to combat HIV are therefore aimed at both of those receptors genes. The gene could be modified in a way that can make them naturally immune to HIV!
Matthew Porteus, MD, an associate professor at Stanford and a pediatric oncologist at Lucile Packard Children’s hospital, and chief investigator said:

"We inactivated one of the receptors that HIV uses to gain entry and added new genes to protect against HIV, so we have multiple layers of protection, what we call stacking. We can use this strategy to make cells that are resistant to both major types of HIV."

These findings are published in “Molecular therapy” which describes the use of “molecular scissors” to cut and paste several HIV-resistant genes into T cells.

This new technique could eventually replace drug treatment all together. As the study was done in laboratory, it further needs clinical trials to prove that this would be functional as complete therapy. Scientists are optimistic. Providing T cells to infected person will not cure infection, but it would provide them protected set of T cell and thus will develop their immune system that is against AIDS.

Through both the CXCR4 and CCR5 receptors and combining the three immune genes, helped guard the cell from HIV. The triple modified genes were the most immune to infection. The T cells that were not modified here the positive control, ended up giving to infection within 25 days.

This is also considered as a stepping stone in gene therapy development for HIV. The next step in this is to test this technique in T cells taken from AIDS patients directly and move further towards animal testing and clinical trials!
Like Post Reply

Possibly Related Threads…
Last Post

Users browsing this thread:
1 Guest(s)

Scientists Successfully Develop HIV-Resistant T-cells !00