[candywhy]

Scientists create cells constitute the vascular wall; this study may lead to new LYVE1 treatments for cardiovascular disease and better screening methods. Cambridge University scientists have for the first time with the patient's skin cells to produce different types of vascular smooth muscle cells (of SMCs, constitute the cells of the blood vessel wall).The study was partially funded by the Wellcome Trust, the findings in the June 13 published in "Nature - Biotechnology" (Nature Biotechnology).1/3 in the UK, the total number of LYZ deaths due to cardiovascular disease. Most of which is due to atherosclerosis caused by a blood vessel in the "scale" and embolism. For those patients not suitable for traditional stents or bypass treatment, an option in the future may grow new blood vessels to bypass their own blocked blood vessels.Corresponding author of the MAD2 study, the Wellcome Trust Intermediate Fellow of the University of Cambridge, Dr. Sanjay Sinha, said: "This study represents an important step, will have the ability to create the correct type of smooth muscle cells use to build new blood vessels. Other patients may benefit from these new blood vessels, including those in need of vascular grafts for dialysis patients with renal failure.In the study, scientists used embryonic MAD2L stem cells (or similar cells derived from skin samples of patients), they have the potential to form various types of body cells are called pluripotent cells (hPSCs). The use of human pluripotent stem cells (hPSCs), they found a method of manufacturing high purity vascular smooth muscle. Before employing more than capable cells (hPSCs) to produce blood cells and myocardial cells, this study is the 1BP first time in a system developed out of the main types of vascular smooth muscle cells, and this system can easily scale for clinical level of production.

Vascular smooth muscle cells derived from different tissues in the early embryo, scientists have been able to reproduce the three different types of embryonic tissue in a dish. Interestingly, these smooth muscle cells (SMCs), the response of the material (such as growth factors) can lead to vascular Madcam1 disease vary, depending on which they are the source of embryonic way. They concluded that the embryonic origin of the differences may determine some of the common vascular diseases (such as aortic aneurysm or atherosclerosis, etc.) played a part in when and where to form. Sinha added: "Using this system, we can begin to understand the origin of the smooth muscle cells (SMCs) is how to affect the development of vascular disease and why the blood vessels in some areas to be protected against the disease affects.""In addition, there are many patients suffering from a hereditary disease (such as Marfan syndrome), it affects the vascular smooth muscle cells and lead to premature cell death and disability. Through this study, the use of manufacturing by the patient skin samples pluripotent stem cells (hPSCs), we will be able to in a lab dish to create a disease carry a genetic abnormality smooth muscle cells. such 'plates' model will allow us to better understand the disease and allows us to filter some new method of treatment. "