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A New Kinetic Structured Model for Cell Cultivation in a Chemostat
#21
Hi Sergey, we have at least one expert on the forum on fermentation
http://www.biotechnologyforums.com/user-15179.html

You can start a new discussion and invite him to participate ..
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#22
Thanks, Dear Administrator.
Our software is almost ready. Small details remained to finish.However, we could do calculations to simulate the growth curves of biomass (S- shaped curves) for the products and substrates.
Until the end of June (the estimated period of free time ) I will able to do about 10 calculations free for the first 10 interested persons.
Leave here the first 10 e-mail addresses.And call your name. I will write to you and we will discuss all after that.
I will provide a link (in the summer or early fall), where our software will be placed-for all the others.
Regards,
Sergey
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#23
New fermentation software promo video:

[/url]
 [url=https://drive.google.com/folderview?id=0B2EolZ66jVIYb1hWNmVlZjI4RzA&usp=sharing]https://drive.google.com/folderview?id=0B2EolZ66jVIYb1hWNmVlZjI4RzA&usp=sharing
 

If the link will change, I 'll let you know.

Sergey
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#24
http://www.youtube.com/watch?v=gEAZXP8R2yI
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#25
Our software will help you solve the following tasks:
a. modeling of your fermentation process data;
b. predicting of the optimal processes;
c. detecting of the limiting substrates according to 'a' and then to do all the calculations to achieve forecasts 'b'.

This is an unique software. Now I'm sending some materials and test calculations for different biomass, products, substrates (including C, N, P, Mg, S). The software is appropriate for calculations of all S-shaped curves for all batch processes. 
    Please note:

 

1) The data for the biomass should be as S- shaped curves (!) 

 
2)  The software minimal quantity of dots for the Biomass,X=f(t), should be equal no less than 8 . (~4 dots  for Exponential Phase of the      growth curve and ~4 dots for Slow Phase.) 
3) The stationary growth phase has a little significance for our software. If you have doubts about your data, please, check them 

    through charting in the Excel programm.

WE INVITE TO JOIN US.
WRITE ME AT MY id:
smlk03@mail.ru
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#26
Hi Sergey,

I encountered this question on biotechnologyforums: http://www.biotechnologyforums.com/threa...l#pid10333 ...... and having read your recent post, I thought you could be an expert to answer. Could you please share your expertise? I am curious to know the answer..
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#27
Dear stevewoods,I see the correct answers to basic questions to the discussion threads. I am engaged in optimization of microbial growth and biosynthesis using our new theory. If it is interesting for you, we could discuss it and work.
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#28
(02-08-2016, 03:39 PM)stevewoods Wrote: Hi Sergey,

I encountered this question on biotechnologyforums: http://www.biotechnologyforums.com/threa...l#pid10333 ...... and having read your recent post, I thought you could be an expert to answer. Could you please share your expertise? I am curious to know the answer..

?
Hello colleagues!
Do you have your activity on this forum?
Greetings,
Sergey Klykov
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#29
Dear colleagues,

You could estimate new design and content of our website,English version: http://www.fermentertool.com/en
If you have your questions,you could leave it directly in chat from your account.
Mobile version is also ready.
The main essence of these models is the following (without mathematics only physics / biology/efficiency):
1) A structure of any cell population is heterogenous, but changes by a strictly pathway.
This was done both for the logarithmic growth phase ,LGP ,and for the growth inhibition phase ,GIP-slow phase.
We have shown this pathway; and all corresponding equations were given in our article/s, please see above.
This allows for vaccines and probiotics producers and for producers that are needed of a biomass with high survival rate of cells to do full controling of cells survival rate.

2) Physiological processes occurring in proliferating and stable (nonproliferating) cells greatly differ and work in opposite directions. In this model we assume that metabolites are synthesized only by proliferating cells,Xdiv. Nonproliferating cells, Xst,as a rule destroy these products.
Therefore, signs of the constants, that describe the rates of the metabolite synthesis and degradation are opposite.
Similar arguments can be applied for substrates used for cell construction.
This is the main answer to the question "what is this?" This is a short guide to FermenterTool software.
Questions for you:
Do you know all possibilities of your fermantation processes? Do you know how much substrates are expended for "negative" side? If you don't know, we are inviting you to begin this work here: http://fermentertool.com/tool
You and/or your colleagues could do all these procedures quickly to achieve maximum of economic efficiency for the fermentation processes by the software using. All the details can be explained in the training.
Please pay attention again to this:

I propose to think about precising of our common plans to move to a direction of increasing and improvement of our cooperation to get fruitful cooperation as a result. I mean our new fermentation software called Fermentertool: http://fermentertool.com/tool/
Begin to make calculations and get new results to improve your fermentation processes. Your competitive advantages will be increased many times. In addition you will take a new look at your processes and you will be able to manage them for real with the goal of excellent economic efficiency.
If you are engaged in science, only this software will give you the opportunity to look with new eyes on your subject of research. Write me at smlk03@mail.ru or klykov10@gmail.com and we will discuss all details for the software using.
If you will read articles on this topic and doing your tests in the software, you will begin to understand it more and more... Our 'community' should be based on these principles: http://www.f.waseda.jp/sidoli/Kuhn_Struc...utions.pdf
For example.
We all were learning in our universities about the J.Monod model and about Monod constant, Ks. What does it mean this constant? Yes, of course, it is the substrate concentration, when we will have specific growth rate 'mu'=1/2*'mu' max.
But, why is it equal 1/2?? Nobody knows about it:-)...
And thus, many great scientists in the field of fermentation recognize the inadequacy of our knowledge.
You could read this here:
[1]. Pirt S J 1975 Principles of Microbe and Cell Cultivation (Oxford: Blackwell)
[2]. Bailey J E and Ollis D F 1986 Biochemical Engineering Fundamentals 2nd edn (New York: McGraw-Hill)
We are proposing new understanding of the Monod model, saturation constant, Ks, based on our theory, that has no exceptions:
http://www.bioprocessintl.com/upstream-p...at-335634/

Greetings,
Sergey Klykov
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A New Kinetic Structured Model for Cell Cultivation in a Chemostat32